Article
Therapy-induced DNA methylation inactivates MCT1 and renders tumor cells vulnerable to MCT4 inhibition.
Cell reports - 1 Jun 2021
Vander Linden Catherine, Corbet Cyril, Bastien Estelle, Martherus Ruben, Guilbaud Céline, Petit Laurenne, Wauthier Loris, Loriot Axelle, De Smet Charles, Feron Olivier
Abstract excerpt
Metabolic plasticity in cancer cells makes use of metabolism-targeting agents very challenging. Drug-induced metabolic rewiring may, however, uncover vulnerabilities that can be exploited. We report that resistance to glycolysis inhibitor 3-bromopyruvate (3-BrPA) arises from DNA methylation in treated cancer cells and subsequent silencing of the monocarboxylate transporter MCT1. We observe that, unexpectedly,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.