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BORCS6 is involved in the enlargement of lung lamellar bodies in Lrrk2 knockout mice

26 May 2021

Abstract excerpt

Leucine-rich repeat kinase 2 (LRRK2) has been implicated in the pathogenesis of Parkinson disease. It has been shown that Lrrk2 knockout (KO) rodents have enlarged lamellar bodies (LBs) in their alveolar epithelial type II cells, although the underlying mechanisms remain unclear. Here we performed proteomic analyses on LBs isolated from Lrrk2 KO mice and found that the LB proteome is substantially different in...

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PMID: 34077533
DOI: 10.1093/hmg/ddab146

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