Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A mutation in Rab38 small GTPase causes abnormal lung surfactant homeostasis and aberrant alveolar structure in mice.

The American journal of pathology - 1 Nov 2008

Osanai Kazuhiro, Oikawa Rieko, Higuchi Junko, Kobayashi Makoto, Tsuchihara Katsuma, Iguchi Masaharu, Jongsu Huang, Toga Hirohisa, Voelker Dennis R

Abstract excerpt

The chocolate mutation, which is associated with oculocutaneous albinism in mice, has been attributed to a G146T transversion in the conserved GTP/GDP-interacting domain of Rab38, a small GTPase that regulates intracellular vesicular trafficking. Rab38 displays a unique tissue-specific expression pattern with highest levels present in the lung. The purpose of this study was to characterize the effects of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Albinism
Share to Guanosine Triphosphate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Monomeric GTP-Binding Proteins

Share to Organ Size

Share to Pressure

Share to Pulmonary Alveoli

Share to Pulmonary Surfactants

Share to rab GTP-Binding Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 18832574
DOI: 10.2353/ajpath.2008.080056
PMCID: PMC2570118

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A mutation in Rab38 small GTPase causes abnormal lung surfactant homeostasis and aberrant alveolar structure in mice.PMID 18832574Read ↗

Altered lung surfactant system in a Rab38-deficient rat model of Hermansky-Pudlak syndrome.Semantic proximity Read ↗

Mutation of melanosome protein RAB38 in chocolate mice.Semantic proximity Read ↗

Rab38 targets to lamellar bodies and normalizes their sizes in lung alveolar type II epithelial cells.Semantic proximity Read ↗

Genetic disorders of surfactant homeostasis.Semantic proximity Read ↗

ABCA3 inactivation in mice causes respiratory failure, loss of pulmonary surfactant, and depletion of lung phosphatidylglycerol.Semantic proximity Read ↗

A dominant negative variant of RAB5B disrupts maturation of surfactant protein B and surfactant protein C.Semantic proximity Read ↗

BORCS6 is involved in the enlargement of lung lamellar bodies in Lrrk2 knockout miceSemantic proximity Read ↗

Rab proteins and Rab-associated proteins: major actors in the mechanism of protein-trafficking disordersSemantic proximity Read ↗

Genetic disorders of surfactant homeostasis.Semantic proximity Read ↗

BORCS6 is involved in the enlargement of lung lamellar bodies in <i>Lrrk2</i> knockout miceSemantic proximity Read ↗

Pulmonary alveolar proteinosis: a review.Semantic proximity Read ↗

Rab38 and Rab32 control post-Golgi trafficking of melanogenic enzymes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.