Article
Deletion of myosin VI causes slow retinal optic neuropathy and age-related macular degeneration (AMD)-relevant retinal phenotype.
Cellular and molecular life sciences : CMLS - 1 Oct 2015
Schubert Timm, Gleiser Corinna, Heiduschka Peter, Franz Christoph, Nagel-Wolfrum Kerstin, Sahaboglu Ayse, Weisschuh Nicole, Eske Gordon, Rohbock Karin, Rieger Norman, Paquet-Durand François, Wissinger Bernd, Wolfrum Uwe, Hirt Bernhard, Singer Wibke, Rüttiger Lukas, Zimmermann Ulrike, Knipper Marlies
Abstract excerpt
The unconventional myosin VI, a member of the actin-based motor protein family of myosins, is expressed in the retina. Its deletion was previously shown to reduce amplitudes of the a- and b-waves of the electroretinogram. Analyzing wild-type and myosin VI-deficient Snell's Waltzer mice in more detail, the expression pattern of myosin VI in retinal pigment epithelium, outer limiting membrane, and outer plexiform...
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