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Article

One Week of CDAHFD Induces Steatohepatitis and Mitochondrial Dysfunction with Oxidative Stress in Liver.

International journal of molecular sciences - 29 May 2021

Sugasawa Takehito, Ono Seiko, Yonamine Masato, Fujita Shin-Ichiro, Matsumoto Yuki, Aoki Kai, Nakano Takuro, Tamai Shinsuke, Yoshida Yasuko, Kawakami Yasushi, Takekoshi Kazuhiro

Abstract excerpt

The prevalence of nonalcoholic fatty liver disease (NAFLD) has been rapidly increasing worldwide. A choline-deficient, L-amino acid-defined, high-fat diet (CDAHFD) has been used to create a mouse model of nonalcoholic steatohepatitis (NASH). There are some reports on the effects on mice of being fed a CDAHFD for long periods of 1 to 3 months. However, the effect of this diet over a short period is unknown....

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Identifiers

PMID: 34072586
DOI: 10.3390/ijms22115851
PMCID: PMC8198552

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