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A genetic variant in telomerase reverse transcriptase (TERT) modifies cancer risk in Lynch syndrome patients harbouring pathogenic MSH2 variants.

Scientific reports - 31 May 2021

Wiik Mariann Unhjem, Evans Tiffany-Jane, Belhadj Sami, Bolton Katherine A, Dymerska Dagmara, Jagmohan-Changur Shantie, Capellá Gabriel, Kurzawski Grzegorz, Wijnen Juul T, Valle Laura, Vasen Hans F A, Lubinski Jan, Scott Rodney J, Talseth-Palmer Bente A

Abstract excerpt

Individuals with Lynch syndrome (LS), have an increased risk of developing cancer. Common genetic variants of telomerase reverse transcriptase (TERT) have been associated with a wide range of cancers, including colorectal cancer (CRC) in LS. We combined genotype data from 1881 LS patients, carrying pathogenic variants in MLH1, MSH2 or MSH6, for rs2075786 (G>A, intronic variant), 1207 LS patients for rs2736108...

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Share to Aged, 80 and over
Share to Chromosomes, Human, Pair 5
Share to Colorectal Neoplasms
Share to Colorectal Neoplasms, Hereditary Nonpolyposis
Share to MutS Homolog 2 Protein
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Identifiers

PMID: 34059744
DOI: 10.1038/s41598-021-90501-2
PMCID: PMC8166931

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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