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Article

Activation of the basal cell carcinoma pathway in a patient with CNS HGNET-BCOR diagnosis: consequences for personalized targeted therapy.

Oncotarget - 13 Dec 2016

Paret Claudia, Theruvath Johanna, Russo Alexandra, Kron Bettina, El Malki Khalifa, Lehmann Nadine, Wingerter Arthur, Neu Marie A, Gerhold-Ay Aslihan, Wagner Wolfgang, Sommer Clemens, Pietsch Torsten, Seidmann Larissa, Faber Jörg

Abstract excerpt

High grade neuroepithelial tumor of the central nervous system with BCOR alteration (CNS HGNET-BCOR) is a recently described new tumor entity with a dismal prognosis. The objective of this study was to identify and validate pathways deregulated in CNS HGNET-BCOR as basis for targeted therapy approaches.We characterized the BCOR alteration in a pediatric patient with CNS HGNET-BCOR diagnosis by Sanger sequencing...

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Identifiers

PMID: 27825128
DOI: 10.18632/oncotarget.13092
PMCID: PMC5347776

Genes

BCOR
SHH
AXIN2
GLI1
PTCH1
SMO
SUFU

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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