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Triglyceride-lowering LPL alleles combined with LDL-C-lowering alleles are associated with an additively improved lipoprotein profile.

Atherosclerosis - 1 Jul 2021

Ibi Dorina, Blauw Lisanne L, Noordam Raymond, Dollé Martijn E T, Jukema J Wouter, Rosendaal Frits R, Christodoulides Constantinos, Neville Matt J, Koivula Robert, Rensen Patrick C N, Karpe Fredrik, van Dijk Ko Willems

Abstract excerpt

BACKGROUND AND AIMS: Mendelian randomization studies have shown that triglyceride (TG)- lowering lipoprotein lipase (LPL) alleles and low-density lipoprotein-cholesterol (LDL-C)-lowering alleles have independent beneficial associations on cardiovascular disease (CVD) risk. We aimed to provide further insight into this observation by applying Mendelian randomization analyses of genetically-influenced TG and LDL-C...

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PMID: 34053745
DOI: 10.1016/j.atherosclerosis.2021.04.015

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