Article
Predictive nomogram for leprosy using genetic and epidemiological risk factors in Southwestern China: Case-control and prospective analyses.
EBioMedicine - 1 Jun 2021
Long Si-Yu, Sun Ji-Ya, Wang Le, Long Heng, Jiang Hai-Qin, Shi Ying, Zhang Wen-Yue, Xiong Jing-Shu, Sun Pei-Wen, Chen Yan-Qing, Mei You-Ming, Pan Chun, Wang Zhen-Zhen, Wu Zi-Wei, Wu Ai-Ping, Yu Mei-Wen, Wang Hong-Sheng
Abstract excerpt
BACKGROUND: There is a high incidence of leprosy among house-contacts compared with the general population. We aimed to establish a predictive model using these genetic factors along with epidemiological factors to predict leprosy risk of leprosy household contacts (HHCs). METHODS: Weighted genetic risk score (wGRS) encompassing genome wide association studies (GWAS) variants and five non-genetic factors were...
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