Article
Longitudinal analysis reveals that delayed bystander CD8+ T cell activation and early immune pathology distinguish severe COVID-19 from mild disease.
Immunity - 8 Jun 2021
Bergamaschi Laura, Mescia Federica, Turner Lorinda, Hanson Aimee L, Kotagiri Prasanti, Dunmore Benjamin J, Ruffieux Hélène, De Sa Aloka, Huhn Oisín, Morgan Michael D, Gerber Pehuén Pereyra, Wills Mark R, Baker Stephen, Calero-Nieto Fernando J, Doffinger Rainer, Dougan Gordon, Elmer Anne, Goodfellow Ian G, Gupta Ravindra K, Hosmillo Myra, Hunter Kelvin, Kingston Nathalie, Lehner Paul J, Matheson Nicholas J, Nicholson Jeremy K, Petrunkina Anna M, Richardson Sylvia, Saunders Caroline, Thaventhiran James E D, Toonen Erik J M, Weekes Michael P, Göttgens Berthold, Toshner Mark, Hess Christoph, Bradley John R, Lyons Paul A, Smith Kenneth G C
Abstract excerpt
The kinetics of the immune changes in COVID-19 across severity groups have not been rigorously assessed. Using immunophenotyping, RNA sequencing, and serum cytokine analysis, we analyzed serial samples from 207 SARS-CoV2-infected individuals with a range of disease severities over 12 weeks from symptom onset. An early robust bystander CD8+ T cell immune response, without systemic inflammation, characterized...
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