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Article

Pharmacological targeting of TNS3 with histone deacetylase inhibitor as a therapeutic strategy in esophageal squamous cell carcinoma.

Aging - 28 May 2021

Shi Yang, Xiang Zheng, Yang Huiyu, Khan Suliman, Li Ruizhe, Zhou Siran, Ullah Saif, Zhang Jiyu, Liu Bingrong

Abstract excerpt

Histone acetylation which regulates about 2-10% of genes has been demonstrated to be involved in tumorigenesis of esophageal squamous cell carcinoma (ESCC). In this study, we investigated the treatment response of ESCC to selective histone deacetylase inhibitor (HDACi) LMK-235 and potential biomarker predicting the treatment sensitivity. We identified tensin-3 (TNS3) which was highly over-expressed in ESCC as one...

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Identifiers

PMID: 34047714
DOI: 10.18632/aging.203091
PMCID: PMC8221360

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