Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inhibited HDAC3 promotes microRNA-376c-3p to suppress malignant phenotypes of gastric cancer cells by reducing WNT2b.

Genomics - 1 Nov 2021

Zhang Lan, Liu Fanglin, Meng Zhixing, Luo Qingyue, Pan Daojing, Qian Yihua

Abstract excerpt

OBJECTIVE: Our study aims to identify the impact of histone deacetylase 3 (HDAC3) and microRNA-376c-3p (miR-376c-3p) on gastric cancer (GC) by targeting wingless-type MMTV integration site family member 2b (WNT2b). METHODS: Levels of miR-376c-3p, HDAC3 and WNT2b were assessed. GC cells were treated with altered HDAC3 or miR-376c-3p to evaluate their biological functions, and rescue experiment was performed to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Proliferation
Share to Glycoproteins
Share to Histone Deacetylases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to MicroRNAs

Share to Phenotype

Share to Stomach Neoplasms

Share to Wnt Proteins

Source

Identifiers

PMID: 34284078
DOI: 10.1016/j.ygeno.2021.07.018

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inhibited HDAC3 promotes microRNA-376c-3p to suppress malignant phenotypes of gastric cancer cells by reducing WNT2b.PMID 34284078Read ↗

HDAC4 promotes the growth and metastasis of gastric cancer via autophagic degradation of MEKK3Semantic proximity Read ↗

Targeting Wnt Signaling for the Treatment of Gastric Cancer.Semantic proximity Read ↗

Histone Deacetylases (HDACs) in Gastric Cancer: An Update of their Emerging Prognostic and Therapeutic RoleSemantic proximity Read ↗

Acetyltransferase NAT10 promotes gastric cancer progression by regulating the Wnt/β-catenin signaling pathway and enhances chemotherapy resistanceSemantic proximity Read ↗

MicroRNA-200b reduced ZEB1 to inhibit cell proliferation and migration in human gastric cancerSemantic proximity Read ↗

miR-367-3p enhanced gastric cancer progression by targeting Smad7 to regulate the transforming growth factor-1/Smad3 pathwaySemantic proximity Read ↗

The inhibition of histone deacetylase 8 suppresses proliferation and inhibits apoptosis in gastric adenocarcinomaSemantic proximity Read ↗

NUAK1 activates STAT5/GLI1/SOX2 signaling to enhance cancer cell expansion and drives chemoresistance in gastric cancerSemantic proximity Read ↗

Histone Deacetylase Functions in Gastric Cancer: Therapeutic Target?Semantic proximity Read ↗

The expression of histone deacetylase HDAC1 correlates with the progression and prognosis of gastrointestinal malignancySemantic proximity Read ↗

STAT3 Pathway in Gastric Cancer: Signaling, Therapeutic Targeting and Future ProspectsSemantic proximity Read ↗

INHBA gene silencing inhibits gastric cancer cell migration and invasion by impeding activation of the TGF‐β signaling pathwaySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.