Article
Association of cystic fibrosis transmembrane conductance regulator with epithelial sodium channel subunits carrying Liddle's syndrome mutations.
American journal of physiology. Lung cellular and molecular physiology - 1 Aug 2021
Rooj Arun K, Cormet-Boyaka Estelle, Clark Edlira B, Qadri Yawar J, Lee William, Boddu Ravindra, Agarwal Anupam, Tambi Richa, Uddin Mohammed, Parpura Vladimir, Sorscher Eric J, Fuller Cathy M, Berdiev Bakhrom K
Abstract excerpt
The association of the cystic fibrosis transmembrane conductance regulator (CFTR) and epithelial sodium channel (ENaC) in the pathophysiology of cystic fibrosis (CF) is controversial. Previously, we demonstrated a close physical association between wild-type (WT) CFTR and WT ENaC. We have also shown that the F508del CFTR fails to associate with ENaC unless the mutant protein is rescued pharmacologically or by low...
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