Article
Stabilizing rescued surface-localized δf508 CFTR by potentiation of its interaction with Na(+)/H(+) exchanger regulatory factor 1.
Biochemistry - 1 Jul 2014
Arora Kavisha, Moon Changsuk, Zhang Weiqiang, Yarlagadda Sunitha, Penmatsa Himabindu, Ren Aixia, Sinha Chandrima, Naren Anjaparavanda P
Abstract excerpt
Cystic fibrosis (CF) is a recessive genetic disease caused by mutations in CFTR, a plasma-membrane-localized anion channel. The most common mutation in CFTR, deletion of phenylalanine at residue 508 (ΔF508), causes misfolding of CFTR resulting in little or no protein at the plasma membrane. The C...
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