Article
Host-mediated selection impacts the diversity of Plasmodium falciparum antigens within infections.
Nature communications - 11 Apr 2018
Early Angela M, Lievens Marc, MacInnis Bronwyn L, Ockenhouse Christian F, Volkman Sarah K, Adjei Samuel, Agbenyega Tsiri, Ansong Daniel, Gondi Stacey, Greenwood Brian, Hamel Mary, Odero Chris, Otieno Kephas, Otieno Walter, Owusu-Agyei Seth, Asante Kwaku Poku, Sorgho Hermann, Tina Lucas, Tinto Halidou, Valea Innocent, Wirth Dyann F, Neafsey Daniel E
Abstract excerpt
Host immunity exerts strong selective pressure on pathogens. Population-level genetic analysis can identify signatures of this selection, but these signatures reflect the net selective effect of all hosts and vectors in a population. In contrast, analysis of pathogen diversity within hosts provides information on individual, host-specific selection pressures. Here, we combine these complementary approaches in an...
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