Whole-genome scans provide evidence of adaptive evolution in Malawian Plasmodium falciparum isolates.

doi:10.1093/infdis/jiu349

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Article

Whole-genome scans provide evidence of adaptive evolution in Malawian Plasmodium falciparum isolates.

The Journal of infectious diseases - 15 Dec 2014

Ocholla Harold, Preston Mark D, Mipando Mwapatsa, Jensen Anja T R, Campino Susana, MacInnis Bronwyn, Alcock Daniel, Terlouw Anja, Zongo Issaka, Oudraogo Jean-Bosco, Djimde Abdoulaye A, Assefa Samuel, Doumbo Ogobara K, Borrmann Steffen, Nzila Alexis, Marsh Kevin, Fairhurst Rick M, Nosten Francois, Anderson Tim J C, Kwiatkowski Dominic P, Craig Alister, Clark Taane G, Montgomery Jacqui

Abstract excerpt

BACKGROUND: Selection by host immunity and antimalarial drugs has driven extensive adaptive evolution in Plasmodium falciparum and continues to produce ever-changing landscapes of genetic variation. METHODS: We performed whole-genome sequencing of 69 P. falciparum isolates from Malawi and used population genetics approaches to investigate genetic diversity and population structure and identify loci under...

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PMID: 24948693
DOI: 10.1093/infdis/jiu349
PMCID: PMC4241944

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