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Passing experiences on to future generations: endocrine disruptors and transgenerational inheritance of epimutations in brain and sperm

2 Nov 2018

Abstract excerpt

All animals have body burdens of polychlorinated biphenyls (PCBs) despite their ban decades ago. These and modern endocrine-disrupting chemicals (EDCs) such as the fungicide vinclozolin (VIN) perturb hormone signaling and lead to dysfunctions following prenatal exposures. Beyond direct exposures, transgenerational disease phenotypes can persist for multiple generations without subsequent exposure. The mechanisms...

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PMID: 30444163
DOI: 10.1080/15592294.2018.1543506

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