Article
Developmental effects of an environmental antiandrogen: the fungicide vinclozolin alters sex differentiation of the male rat.
Toxicology and applied pharmacology - 1 Nov 1994
Gray L E, Ostby J S, Kelce W R
Abstract excerpt
In humans and rodents, exposure to hormonally active chemicals during sex differentiation can produce a wide range of abnormal sexual phenotypes including masculinized and defeminized females and feminized and demasculinized males. Although numerous "environmental estrogens," including pesticides, toxic substances (PCBs), and plant and fungal estrogens, have been shown to alter mammalian sex differentiation,...
Topics
- Administration, Oral
- Analysis of Variance
- Androgen Antagonists
- Animals
- Body Weight
- Computer Simulation
- Ejaculation
- Embryonic and Fetal Development
- Endocrine Glands
- Environmental Pollutants
- Female