Article
Sex-dependent effects of genetic upregulation of activated protein C on delayed effects of acute radiation exposure in the mouse heart, small intestine, and skin.
PloS one - 1 Jan 2021
Sridharan Vijayalakshmi, Johnson Kristin A, Landes Reid D, Cao Maohua, Singh Preeti, Wagoner Gail, Hayar Abdallah, Sprick Emily D, Eveld Kayla A, Bhattacharyya Anusha, Krager Kimberly J, Aykin-Burns Nukhet, Weiler Hartmut, Fernández Jose A, Griffin John H, Boerma Marjan
Abstract excerpt
Accidental exposure to ionizing radiation may lead to delayed effects of acute radiation exposure (DEARE) in many organ systems. Activated protein C (APC) is a known mitigator of the acute radiation syndrome. To examine the role of APC in DEARE, we used a transgenic mouse model with 2- to 3-fold increased plasma levels of APC (high in APC, APCHi). Male and female APCHi mice and wild-type littermates were exposed...
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