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Article

Human primary retinal cells as an in-vitro model for investigating defective signalling caused by OPTN mutants associated with glaucoma.

Neurochemistry international - 1 Sept 2021

Sayyad Zuberwasim, Vishwakarma Sushma, Dave Tarjani Vivek, Naik Milind N, Radha Vegesna, Kaur Inderjeet, Swarup Ghanshyam

Abstract excerpt

Studies carried out on the pathogenesis of glaucoma using murine cell lines and animal models require to be validated in human cells. Therefore, we explored the possibility of using human primary retinal cells (hPRCs) in culture as a model for molecular studies and testing of potential therapeutic drugs. For this purpose, central retinal tissue, obtained from the enucleated eyes of patients with anterior...

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Source

Identifiers

PMID: 34023378
DOI: 10.1016/j.neuint.2021.105075

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Human primary retinal cells as an in-vitro model for investigating defective signalling caused by OPTN mutants associated with glaucoma.PMID 34023378Read ↗

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