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USP18 Mediates Interferon Resistance of Dengue Virus Infection

30 Apr 2021

Abstract excerpt

Previous studies demonstrated that dengue virus (DENV) infection developed resistance to type-I interferons (IFNα/β). The underlying mechanism remains unclear. USP18 is a negative regulator of IFNα/β signaling, and its expression level is significantly increased following DENV infection in cell lines and patients' blood. Our previous study revealed that increased USP18 expression contributed to the IFN-α...

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PMID: 34017322
DOI: 10.3389/fmicb.2021.682380

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