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Sequential deletion of CD63 identifies topologically distinct scaffolds for surface engineering of exosomes in living human cells

1 Jan 2020

Abstract excerpt

Exosomes are cell-derived extracellular vesicles that have great potential in the field of nano-medicine. However, a fundamental challenge in the engineering of exosomes is the design of biocompatible molecular scaffolds on their surface to enable cell targeting and therapeutic functions. CD63 is a hallmark protein of natural exosomes that is highly enriched on the external surface of the membrane. We have...

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PMID: 32463402
DOI: 10.1039/d0nr00362j

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