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Article

Increased Dysfunctional and Plastic Regulatory T Cells in Idiopathic Orbital Inflammation.

Frontiers in immunology - 1 Jan 2021

Chen Jingqiao, Ye Huijing, Xiao Wei, Mao Yuxiang, Ai Siming, Chen Rongxin, Lian Xiufen, Shi Lu, Wang Xing, Bi Shaowei, Yang Shenglan, Ji Xian, Zhang Te, Yang Huasheng

Abstract excerpt

Background: Idiopathic orbital inflammation (IOI) is a disfiguring and vision-threatening fibroinflammatory disorder. The pathogenesis of IOI has not been elucidated. We sought to clarify the regulatory T cell (Treg) distribution and function in patients with IOI. Methods: The frequency, phenotype and function of Tregs were identified by multicolor flow cytometry and in vitro cell functional assays. Plasma and...

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Identifiers

PMID: 34012433
DOI: 10.3389/fimmu.2021.634847
PMCID: PMC8126653

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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