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Article

Detection of von Hippel-Lindau gene mutation in circulating cell-free DNA for clear cell renal cell carcinoma.

Cancer science - 1 Aug 2021

Sumiyoshi Takayuki, Yamasaki Toshinari, Takeda Masashi, Mizuno Kei, Utsunomiya Noriaki, Sakamoto Hiromasa, Nakamura Eijiro, Ogawa Osamu, Akamatsu Shusuke

Abstract excerpt

The therapeutic landscape of metastatic clear cell renal cell carcinoma (ccRCC) has rapidly expanded, and there is an urgent need to develop noninvasive biomarkers that can select an optimal therapy or evaluate the response in real time. To evaluate the clinical utility of circulating tumor DNA (ctDNA) analysis in ccRCC, we established a highly sensitive assay to detect mutations in von Hippel-Lindau gene (VHL)...

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Share to Biomarkers, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Renal Cell

Share to Case-Control Studies

Share to Cell-Free Nucleic Acids

Share to Cell Line, Tumor

Share to Sequence Analysis, DNA

Share to Von Hippel-Lindau Tumor Suppressor Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 34009695
DOI: 10.1111/cas.14972
PMCID: PMC8353948

Genes

VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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