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Article

Genetics of addictive behavior: the example of nicotine dependence.

Dialogues in clinical neuroscience - 1 Sept 2017

Gorwood Philip, Le Strat Yann, Ramoz Nicolas

Abstract excerpt

The majority of addictive disorders have a significant heritability-roughly around 50%. Surprisingly, the most convincing association (a nicotinic acetylcholine receptor CHRNA5-A3-B4 gene cluster in nicotine dependence), with a unique attributable risk of 14%, was detected through a genome-wide association study (GWAS) on lung cancer, although lung cancer has a low heritability. We propose some explanations of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genetic Predisposition to Disease

Share to Genome-Wide Association Study

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Source

Open in PubMed Open full text

Identifiers

PMID: 29302221
PMCID: PMC5741107

Genes

CHRNA5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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