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Article

Genetic Factors Control Nicotine Self-Administration in Isogenic Adolescent Rat Strains

28 Aug 2012

Abstract excerpt

Adult cigarette smokers usually become dependent on cigarettes during adolescence. Despite recent advances in addiction genetics, little data delineates the genetic factors that account for the vulnerability of humans to smoke tobacco. We studied the operant nicotine self-administration (SA) behavior of six inbred strains of adolescent male rats (Fisher 344, Brown Norway, Dark Agouti, Spontaneous Hypertensive...

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PMID: 22937166
DOI: 10.1371/journal.pone.0044234

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