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Mitochondrial ATP fuels ABC transporter-mediated drug efflux in cancer chemoresistance

14 May 2021

Abstract excerpt

Chemotherapy remains the standard of care for most cancers worldwide, however development of chemoresistance due to the presence of the drug-effluxing ATP binding cassette (ABC) transporters remains a significant problem. The development of safe and effective means to overcome chemoresistance is critical for achieving durable remissions in many cancer patients. We have investigated the energetic demands of ABC...

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PMID: 33990571
DOI: 10.1038/s41467-021-23071-6

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