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Article

Inhibition of DEC2 is necessary for exiting cell dormancy in salivary adenoid cystic carcinoma

14 May 2021

Abstract excerpt

BACKGROUND: Patients were prone to have poor prognosis once dormant tumor cells being reactivated. However, the molecular mechanism of tumor cell dormancy remains poorly understood. This study aimed to investigate the function of DEC2 in the dormancy of salivary adenoid cystic carcinoma (SACC) in vitro and vivo. METHODS: induced hypoxia-mimicking microenvironments. Furthermore, the expression of DEC2 was detected...

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Share to Cancer, Hypoxia, and Metabolism
Share to Salivary Gland Disorders and Functions
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PMID: 33990215
DOI: 10.1186/s13046-021-01956-0

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