Article
The association between ERK inhibitor sensitivity and molecular characteristics in colorectal cancer.
Biochemical and biophysical research communications - 30 Jun 2021
Tayama Hodaka, Karasawa Hideaki, Yamamura Akihiro, Okamura Yasunobu, Katsuoka Fumiki, Suzuki Hideyuki, Kajiwara Taiki, Kobayashi Minoru, Hatsuzawa Yuuri, Shiihara Masahiro, Bin Li, Gazi Md Yeashin, Sato Mizuki, Kumada Kazuki, Ito Shigehiro, Shimada Muneaki, Furukawa Toru, Kamei Takashi, Ohnuma Shinobu, Unno Michiaki
Abstract excerpt
The mitogen-activated protein kinase (MAPK) pathway plays an important role in the colorectal cancer (CRC) progression, being supposed to be activated by the gene mutations, such as BRAF or KRAS. Although the inhibitors of extracellular signal-regulated kinase (ERK) have demonstrated efficacy in the cells with the BRAF or KRAS mutations, a clinical response is not always associated with the molecular signature....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.