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Article

Molecular subtypes of colorectal cancer in pre-clinical models show differential response to targeted therapies: Treatment implications beyond KRAS mutations.

PloS one - 1 Jan 2018

Pal Rekha, Wei Ning, Song Nan, Wu Shaoyu, Kim Rim S, Wang Ying, Gavin Patrick G, Lucas Peter C, Srinivasan Ashok, Allegra Carmen J, Jacobs Samuel A, Paik Soonmyung, Schmitz John C, Pogue-Geile Katherine L

Abstract excerpt

Molecular subtypes of colorectal tumors are associated with prognosis and prediction for treatment benefit from chemotherapy. The purpose of this study was two-fold: 1) to determine the association of colorectal (CRC) molecular subtypes with response to targeted therapies in pre-clinical models and 2) to identify treatments for CRC stem-like subtype because these tumors are associated with a very poor patient...

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Identifiers

PMID: 30118499
DOI: 10.1371/journal.pone.0200836
PMCID: PMC6097647

Genes

KRAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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