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Article

Master regulator analysis of paragangliomas carrying SDHx, VHL, or MAML3 genetic alterations.

BMC cancer - 24 Jun 2019

Smestad John A, Maher L James

Abstract excerpt

BACKGROUND: Succinate dehydrogenase (SDH) loss and mastermind-like 3 (MAML3) translocation are two clinically important genetic alterations that correlate with increased rates of metastasis in subtypes of human paraganglioma and pheochromocytoma (PPGL) neuroendocrine tumors. Although hypotheses propose that succinate accumulation after SDH loss poisons dioxygenases and activates pseudohypoxia and epigenomic...

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Topics

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Share to Adrenal Gland Neoplasms
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Translocation, Genetic

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Source

Open in PubMed Open full text

Identifiers

PMID: 31234811
DOI: 10.1186/s12885-019-5813-z
PMCID: PMC6591808

Genes

MAML3
VHL
EPAS1
ZNF423

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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