Virion-incorporated PSGL-1 and CD43 inhibit both cell-free infection and transinfection of HIV-1 by preventing virus-cell binding.

doi:10.1073/pnas.1916055117

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Article

Virion-incorporated PSGL-1 and CD43 inhibit both cell-free infection and transinfection of HIV-1 by preventing virus-cell binding.

Proceedings of the National Academy of Sciences of the United States of America - 7 Apr 2020

Murakami Tomoyuki, Carmona Nancy, Ono Akira

Abstract excerpt

HIV-1 particles incorporate various host transmembrane proteins in addition to viral Env glycoprotein during assembly at the plasma membrane. In polarized T cells, HIV-1 structural protein Gag localizes to the plasma membrane of uropod, a rear-end protrusion. Notably, uropod transmembrane proteins PSGL-1 and CD43 cocluster specifically with Gag assembling at the plasma membrane even in cells that do not form...

Topics

Blood Buffy Coat
Down-Regulation
Gene Knockout Techniques
HEK293 Cells
HIV Infections
HIV-1
HeLa Cells
Healthy Volunteers
Host-Pathogen Interactions
Humans
Leukosialin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Membrane Glycoproteins

Mutation

Protein Domains

T-Lymphocytes

Virion

Virus Assembly

Virus Attachment

Source

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Identifiers

PMID: 32193343
DOI: 10.1073/pnas.1916055117
PMCID: PMC7148576

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