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Article

Genomic analyses of Mycobacterium tuberculosis from human lung resections reveal a high frequency of polyclonal infections.

Nature communications - 11 May 2021

Moreno-Molina Miguel, Shubladze Natalia, Khurtsilava Iza, Avaliani Zaza, Bablishvili Nino, Torres-Puente Manuela, Villamayor Luis, Gabrielian Andrei, Rosenthal Alex, Vilaplana Cristina, Gagneux Sebastien, Kempker Russell R, Vashakidze Sergo, Comas Iñaki

Abstract excerpt

Polyclonal infections occur when at least two unrelated strains of the same pathogen are detected in an individual. This has been linked to worse clinical outcomes in tuberculosis, as undetected strains with different antibiotic resistance profiles can lead to treatment failure. Here, we examine the amount of polyclonal infections in sputum and surgical resections from patients with tuberculosis in the country of...

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Identifiers

PMID: 33976135
DOI: 10.1038/s41467-021-22705-z
PMCID: PMC8113332

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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