The Association between Genetically Predicted C-Reactive Protein Levels and Risk of Colorectal Cancer in an East Asian Population: Two-Sample Mendelian Randomization.

doi:10.1158/1055-9965.EPI-25-1230

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The Association between Genetically Predicted C-Reactive Protein Levels and Risk of Colorectal Cancer in an East Asian Population: Two-Sample Mendelian Randomization.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 3 Feb 2026

Choi Chang Kyun, Yang Jung-Ho, Shin Min-Ho, Cho Sang-Hee, Jia Wei-Hua, Kim Jeongseon, Shin Aesun, Kim Dong-Hyun, Matsuo Keitaro, Jee Sun Ha, Matsuda Koichi, Gao Yu-Tang, Shu Xiao-Ou, Zheng Wei, Kweon Sun-Seog

Abstract excerpt

BACKGROUND: C-reactive protein (CRP) is a widely used inflammatory biomarker that has been related to colorectal cancer risk. However, observational studies are prone to confounding and reverse causality. METHODS: We conducted a two-sample Mendelian randomization using CRP genome-wide association study (GWAS) data from 59,605 Korean individuals and colorectal cancer GWAS data from 23,572 cases and 48,700 controls...

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PMID: 41236733
DOI: 10.1158/1055-9965.EPI-25-1230

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