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Characterization of Frequently Mutated Cancer Genes and Tumor Mutation Burden in Chinese Breast Cancer

21 Apr 2021

Abstract excerpt

Objectives Various genomic alterations and genomic signatures, including ERBB2 amplification, mutations in PIK3CA, AKT1, and ESR1, and tumor mutational burden (TMB), have become important biomarkers for treatment selection in breast cancer (BC). This study aimed to investigate the mutational features of Chinese early-stage BC patients. Methods Tumors and matched blood samples collected from 589 Chinese patients...

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PMID: 33968723
DOI: 10.3389/fonc.2021.618767

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