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Developmental Profile of Psychiatric Risk Associated With Voltage-Gated Cation Channel Activity.

Biological psychiatry - 15 Sept 2021

Clifton Nicholas E, Collado-Torres Leonardo, Burke Emily E, Pardiñas Antonio F, Harwood Janet C, Di Florio Arianna, Walters James T R, Owen Michael J, O'Donovan Michael C, Weinberger Daniel R, Holmans Peter A, Jaffe Andrew E, Hall Jeremy

Abstract excerpt

BACKGROUND: Recent breakthroughs in psychiatric genetics have implicated biological pathways onto which genetic risk for psychiatric disorders converges. However, these studies do not reveal the developmental time point(s) at which these pathways are relevant. METHODS: We aimed to determine the relationship between psychiatric risk and developmental gene expression relating to discrete biological pathways. We...

Topics

Adult
Bipolar Disorder
Cations
Depressive Disorder, Major
Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
Schizophrenia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33965196
DOI: 10.1016/j.biopsych.2021.03.009
PMCID: PMC8375582

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