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Article

APE1 and SSRP1 is overexpressed in muscle invasive bladder cancer and associated with poor survival

1 Apr 2021

Abstract excerpt

BACKGROUND: Human apurinic/apyrimidinic (AP) endonuclease 1 (APE1) plays a critical role in DNA base excision repair (BER) pathway and has been reported to be overexpressed in multiple cancers. Previously, we have shown that histone chaperone FACT complex (Facilitates Chromatin Transcription, a heterodimer of SSRP1 and SPT16 proteins) facilitates the chromatin access and DNA repair function of APE1, and their...

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PMID: 33948507
DOI: 10.1016/j.heliyon.2021.e06756

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