Article
Joint Effect of Multiple Prothrombotic Genotypes and Obesity on the Risk of Incident Venous Thromboembolism.
Thrombosis and haemostasis - 1 Feb 2022
Frischmuth Tobias, Hindberg Kristian, Gabrielsen Maiken E, Brumpton Ben, Hveem Kristian, Brækkan Sigrid K, Hansen John-Bjarne, Morelli Vânia M
Abstract excerpt
BACKGROUND: The impact of the combination of obesity and multiple prothrombotic genotypes on venous thromboembolism (VTE) risk remains unclear. OBJECTIVE: To investigate the joint effect of obesity and a genetic risk score (GRS) composed of established prothrombotic single nucleotide polymorphisms (SNPs) on VTE risk using a population-based case-cohort. METHODS: Cases with incident VTE (n = 1,470) and a subcohort...
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