Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genome-Wide Gene Expression Analysis of Mtb-Infected DC Highlights the Rapamycin-Driven Modulation of Regulatory Cytokines via the mTOR/GSK-3β Axis

16 Apr 2021

Abstract excerpt

In human primary dendritic cells (DC) rapamycin—an autophagy inducer and protein synthesis inhibitor—overcomes the autophagy block induced by Mycobacterium tuberculosis (Mtb) and promotes a Th1 response via IL-12 secretion. Here, the immunostimulatory activity of rapamycin in Mtb-infected DC was further investigated by analyzing both transcriptome and translatome gene profiles. Hundreds of differentially...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytokine Signaling Pathways and Interactions
Share to interferon and immune responses
Share to PI3K/AKT/mTOR signaling in cancer

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33936070
DOI: 10.3389/fimmu.2021.649475

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 9 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genome-Wide Gene Expression Analysis of Mtb-Infected DC Highlights the Rapamycin-Driven Modulation of Regulatory Cytokines via the mTOR/GSK-3β AxisPMID 33936070Read ↗

Identification and Analysis of Autophagy-Related Genes as Diagnostic Markers and Potential Therapeutic Targets for Tuberculosis Through BioinformaticsSemantic proximity Read ↗

Mycobacterium tuberculosis-induced miR-155 subverts autophagy by targeting ATG3 in human dendritic cellsSemantic proximity Read ↗

Autophagy modulates the Mycobacterium tuberculosis-induced cytokine response.Semantic proximity Read ↗

TRIM27 elicits protective immunity against tuberculosis by activating TFEB-mediated autophagy fluxSemantic proximity Read ↗

Interactions between Autophagy and Inhibitory CytokinesSemantic proximity Read ↗

Autophagy Is an Innate Mechanism Associated with Leprosy PolarizationSemantic proximity Read ↗

Translational profiling of macrophages infected with Leishmania donovani identifies mTOR- and eIF4A-sensitive immune-related transcriptsSemantic proximity Read ↗

FOXO3 Transcription Factor Regulates IL-10 Expression in Mycobacteria-Infected Macrophages, Tuning Their Polarization and the Subsequent Adaptive Immune ResponseSemantic proximity Read ↗

MiR-1303 Regulates Mycobacteria Induced Autophagy by Targeting Atg2BSemantic proximity Read ↗

Interleukin-27 promotes autophagy in human serum-induced primary macrophages via an mTOR- and LC3-independent pathwaySemantic proximity Read ↗

Down regulated lncRNA MEG3 eliminates mycobacteria in macrophages via autophagySemantic proximity Read ↗

T Helper 2 Cytokines Inhibit Autophagic Control of Intracellular Mycobacterium tuberculosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.