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Article

Autophagy modulates the Mycobacterium tuberculosis-induced cytokine response.

Immunology - 1 Nov 2011

Kleinnijenhuis Johanneke, Oosting Marije, Plantinga Theo S, van der Meer Jos W M, Joosten Leo A B, Crevel Reinout V, Netea Mihai G

Abstract excerpt

Both autophagy and pro-inflammatory cytokines are involved in the host defence against mycobacteria, but little is known regarding the effect of autophagy on Mycobacterium tuberculosis (MTB)-induced cytokine production. In the present study, we assessed the effect of autophagy on production of monocyte-derived and T-cell-derived cytokines, and examined whether two functional polymorphisms in autophagy genes led...

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Identifiers

PMID: 21978003
DOI: 10.1111/j.1365-2567.2011.03494.x
PMCID: PMC3209573

Genes

TNF
IRGM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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