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Article

Autophagy Is an Innate Mechanism Associated with Leprosy Polarization

5 Jan 2017

Abstract excerpt

Leprosy is a chronic infectious disease that may present different clinical forms according to the immune response of the host. Levels of IFN-γ are significantly raised in paucibacillary tuberculoid (T-lep) when compared with multibacillary lepromatous (L-lep) patients. IFN-γ primes macrophages for inflammatory activation and induces the autophagy antimicrobial mechanism. The involvement of autophagy in the...

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PMID: 28056107
DOI: 10.1371/journal.ppat.1006103

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