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Article

The relationship between childhood trauma, rs1360780 genotypes, FKBP5 intron 7 methylation and posttraumatic stress disorder in women who have experienced rape.

European journal of psychotraumatology - 1 Dec 2025

Nöthling Jani, Womersley Jacqueline Samantha, Mhlongo Shibe, Lombard Carl, Abrahams Naeemah, Seedat Soraya, Hemmings Sian Megan Joanne

Abstract excerpt

Background: Posttraumatic stress disorder (PTSD) is a common sequela of rape. Dysfunction of the hypothalamic-pituitary-adrenal (HPA) axis, a core regulator of the stress response, has been implicated in the aetiology and chronicity of PTSD. FK506 binding protein (FKBP5) is a co-chaperone and functional regulator of the glucocorticoid receptor and the HPA-axis.Objective: This study investigated main and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40242984
DOI: 10.1080/20008066.2025.2485707
PMCID: PMC12006943

Genes

FKBP5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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