Article
ctDNA Determination of EGFR Mutation Status in European and Japanese Patients with Advanced NSCLC: The ASSESS Study.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Oct 2016
Reck Martin, Hagiwara Koichi, Han Baohui, Tjulandin Sergei, Grohé Christian, Yokoi Takashi, Morabito Alessandro, Novello Silvia, Arriola Edurne, Molinier Olivier, McCormack Rose, Ratcliffe Marianne, Normanno Nicola
Abstract excerpt
INTRODUCTION: To offer patients with EGFR mutation-positive advanced NSCLC appropriate EGFR tyrosine kinase inhibitor treatment, mutation testing of tumor samples is required. However, tissue/cytologic samples are not always available or evaluable. The large, noninterventional diagnostic ASSESS study (NCT01785888) evaluated the utility of circulating free tumor-derived DNA (ctDNA) from plasma for EGFR mutation...
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