Article
Novel insights from the Plasmodium falciparum sporozoite-specific proteome by probabilistic integration of 26 studies.
PLoS computational biology - 1 Apr 2021
Meerstein-Kessel Lisette, Venhuizen Jeron, Garza Daniel, Proellochs Nicholas I, Vos Emma J, Obiero Joshua M, Felgner Philip L, Sauerwein Robert W, Peters Marynthe, Yang Annie S P, Huynen Martijn A
Abstract excerpt
Plasmodium species, the causative agent of malaria, have a complex life cycle involving two hosts. The sporozoite life stage is characterized by an extended phase in the mosquito salivary glands followed by free movement and rapid invasion of hepatocytes in the human host. This transmission stage has been the subject of many transcriptomics and proteomics studies and is also targeted by the most advanced malaria...
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