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Transcriptomics and proteomics reveal two waves of translational repression during the maturation of malaria parasite sporozoites

31 Oct 2019

Abstract excerpt

Plasmodium sporozoites are transmitted from infected mosquitoes to mammals, and must navigate the host skin and vasculature to infect the liver. This journey requires distinct proteomes. Here, we report the dynamic transcriptomes and proteomes of both oocyst sporozoites and salivary gland sporozoites in both rodent-infectious Plasmodium yoelii parasites and human-infectious Plasmodium falciparum parasites. The...

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PMID: 31673027
DOI: 10.1038/s41467-019-12936-6

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