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Article

Interplay between the miRNome and the epigenetic machinery: Implications in health and disease.

Journal of cellular physiology - 1 Nov 2017

Poddar Shagun, Kesharwani Devesh, Datta Malabika

Abstract excerpt

Epigenetics refers to functionally relevant genomic changes that do not involve changes in the basic nucleotide sequence. Majorly, these are of two types: DNA methylation and histone modifications. Small RNA molecules called miRNAs are often thought to mediate post-transcriptional epigenetic changes by mRNA degradation or translational attenuation. While DNA methylation and histone modifications have their own...

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PMID: 28112397
DOI: 10.1002/jcp.25819

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