Article
Secretion of Mutant DNA and mRNA by the Exosomes of Breast Cancer Cells.
Molecules (Basel, Switzerland) - 25 Apr 2021
Andreeva Olga E, Shchegolev Yuri Y, Scherbakov Alexander M, Mikhaevich Ekaterina I, Sorokin Danila V, Gudkova Margarita V, Bure Irina V, Kuznetsova Ekaterina B, Mikhaylenko Dmitry S, Nemtsova Marina V, Bagrov Dmitry V, Krasil'nikov Mikhail A
Abstract excerpt
Exosomes are the small vesicles that are secreted by different types of normal and tumour cells and can incorporate and transfer their cargo to the recipient cells. The main goal of the present work was to study the tumour exosomes' ability to accumulate the parent mutant DNA or RNA transcripts with their following transfer to the surrounding cells. The experiments were performed on the MCF7 breast cancer cells...
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