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Article

Exosomes transmit T790M mutation-induced resistance in EGFR-mutant NSCLC by activating PI3K/AKT signalling pathway.

Journal of cellular and molecular medicine - 1 Jan 2020

Liu Xiaozhen, Jiang Tao, Li Xuefei, Zhao Chao, Li Jiayu, Zhou Fei, Zhang Limin, Zhao Sha, Jia Yijun, Shi Jinpeng, Gao Guanghui, Li Wei, Zhao Jing, Chen Xiaoxia, Su Chunxia, Ren Shengxiang, Zhou Caicun

Abstract excerpt

Emerging evidence has shown that exosomes derived from drug-resistant tumour cells are able to horizontally transmit drug-resistant phenotype to sensitive cells. However, whether exosomes shed by EGFR T790M-mutant-resistant NSCLC cells could transfer drug resistance to sensitive cells has not been investigated. We isolated exosomes from the conditioned medium (CM) of T790M-mutant NSCLC cell line H1975 and...

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Identifiers

PMID: 31894895
DOI: 10.1111/jcmm.14838
PMCID: PMC6991626

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