Article
PPP2R1B is modulated by ubiquitination and is essential for spermatogenesis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 May 2021
Du Mufeng, Yuan Lin, Zhang Zhong, Zhang Cong, Zhu Minglu, Zhang Zhe, Li Ridong, Zhao Xuyang, Liang Hui, Li Yuhua, Jiang Hui, Qiao Jie, Yin Yuxin
Abstract excerpt
The serine-threonine protein phosphatase 2A (PP2A) is a heterotrimeric enzyme complex that regulates many fundamental cellular processes. PP2A is involved in tumorigenesis because mutations in the scaffold subunit, PPP2R1B, were found in several types of cancers. However, the biological function of PPP2R1B remains largely unknown. We report here that homozygous deletion of Ppp2r1b in Mus musculus impairs meiotic...
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