Article
Feasibility of novel PPP1R15A and proposed ANXA11 single nucleotide polymorphisms as predictive markers for bevacizumab regimen in metastatic colorectal cancer.
Journal of cancer research and clinical oncology - 1 Aug 2016
Roh Seon Ae, Park In Ja, Yoon Yong Sik, Kwon Yi Hong, Chung Jin Hwa, Kim Tae Won, Cho Dong Hyung, Lim Byung Ho, Kim Seon Kyu, Kim Seon Young, Kim Yong Sung, Kim Jin Cheon
Abstract excerpt
PURPOSE: Bevacizumab improves survival in patients with metastatic colorectal cancer (mCRC) under chemotherapy, but few predictive markers have been identified. METHODS: To investigate chemosensitive single nucleotide polymorphisms (SNPs) of mCRC, we performed exome sequencing and RNA sequencing in 19 patients. A clinical association analysis was performed with the other 116 patients who had received chemotherapy...
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